Mutaflor: Probiotic Containing Escherichia Coli Nissle 1917
Original article on http://www.probiotics-help.com/mutaflor.html
Mutaflor is the only probiotic supplement on the market containing the friendly bacterium Escherichia coli Nissle 1917. This is a non-pathogenic helpful bacterium, which is NOT to be confused with the disease-causing Escherichia Coli 0157.
The strain contained in this product, Escherichia coli Nissle 1917, is named after the German doctor Professor Alfred Nissle, who first isolated the bacterium in 1917 during the First World War.
- E. coli strain Nissle 1917 (2.5–25 x 109 viable cells (CFU))
- Methacrylic acid-methyl methacrylate copolymer (1:1)
- Dibuytl phthalate
- Titanium dioxide
- Iron (III) hydroxide oxide monohydrate
- Beeswax (yellow)
- Carnauba wax
- Purified water
The capsules are free from gluten, milk proteins and lactose so are suitable for those with allergies or intolerances to these substances. The product does contain gelatin though so is not suitable for vegetarians.
It is also available as a high strength capsule and as a suspension for children in Germany.
Clinical Evidence Supporting Mutaflor
Since it was first isolated, the bacterium contained in Mutaflor has been studied extensively and has been shown in scientific research to help numerous conditions
As well as being able to colonize the gut, biologically fit and active against disease-causing agents known as pathogens1, Escherichia coli Nissle 1917 has been shown in scientific studies to be of benefit for both inflammatory bowel as well as functional bowel disease:
Inflammatory Bowel Disease
- Pouchitis: Induction and maintenance of remission2.
- Ulcerative Colitis: Studies concluded that the use of Mutaflor with mezalasine was effective as a treatment for ulcerative colitis in maintaining remission3,4,5.
- Crohn’s Disease: Fewer relapses in Crohn’s Disease patients taking Mutaflor versus control group (33.3% versus 63.6%)6.
- Pseudomembranous colitis (also known as antibiotic-associated diarrhea and often caused by the bacterium Clostridium Difficile or C. Diff): Helpful when combined with intestinal lavage, otherwise known as colonic hydrotherapy or colonic irrigation7.
Functional Bowel Disorders
- Diverticular Disease: Pilot study concluded that treatment with Mutaflor was helpful in reducing symptoms in diverticulitis8.
- Diarrhea: Mutaflor normalized acute diarrhea more quickly than a placebo9.
- Chronic Constipation: Research concluded Mutaflor was as effective as the laxative lactulose10 and it also increased the number of bowel movements in chronic idiopathic constipation11.
- Irritable Bowel Syndrome: Significant improvement in stool frequency was observed as well as a marked improvement in other symptoms such as abnormal urge, flatulence and abdominal fullness12.
Scientific studies suggest that this probiotic bacterium may be beneficial for a good number of conditions. The capsules are covered in a hard enteric coating to ensure that the friendly bacteria contained inside survive the stomach acid unharmed and are alive and viable when they reach the bowel, where they set to work.
The product can also be taken with or without food and is suitable for use as a long term therapy. According to the manufacturer of the product, Ardeypharm, the product can be taken with certain antibiotics WITHOUT loss of effectiveness. These antibiotics are those that are directed against gram-positive bacteria and include:
- Penicillin G
Antibiotics that are directed against gram-negative bacteria will, however, render the product less effective.
Whilst the product should be kept cool by means of refrigeration, it can be kept at room temperature for short periods of up to 72 hours without any loss of potency. This makes it suitable for taking on short trips away.
Compared to many other probiotic products, Mutaflor has a short shelf life of between three and six months when kept under refrigeration. Please don’t buy in bulk – you will waste your money.
The product also contains a good many additional ingredients such as fillers and preservatives, which may make it difficult to tolerate for the more sensitive patients. The hard enteric capsule also makes it almost impossible to open up the capsule to try just a small amount of the product to begin with. Very sensitive individuals may thus find that the dose of beneficial bacteria contained in a whole capsule may provoke side effects such as gas, changes in stool frequency and nausea in the initial stages of therapy.